• EVOLVEpro, PLMs with active learning, enables rapid and efficient evolution of protein activities. Show promosing optimization of Antibody, CRISPR Nuclease, Prime Editor, Integrase, and T7 RNA Polymerase through experiments
• Use ESM-2-15B for embeddings. Apply a Random Forest regressor on averaged embeddings for function prediction. Start with a random set of first-round variants and use a top-N (low N) selection strategy in each evolution round